This book has built on the work that was presented in the previous Fascicles of the Third and Fourth Series. The authors' vast experience has led to new understanding of many aspects of pituitary pathology. With modern immunostaining and molecular techniques, classification of pituitary disease is becoming easier. Furthermore, the availability of targeted therapies has augmented the role of the pathologist in determining an accurate diagnosis. This updated volume addresses modern techniques and their application to treatment of pituitary neoplasms but retains the detailed foundation of morphology in a lushly illustrated tome, the cornerstone of the AFIP fascicles.

Neuroendocrine neoplasms comprise a large family of proliferative lesions that involve almost every part of the body. Our understanding of their cells of origin as well as the pathology, pathophysiology and genetics of these neoplasms has made tremendous advances in the last few decades. While they are often discussed as separate entities in textbooks of gastroenteropancreatic pathology and pulmonary pathology, their scope is much broader. The book conveys the similarities and differences of these fascinating tumors that may be found from the hypothalamus and pituitary to the rectum, and in soft tissue as well as in many organs. Written by experts in the field, the authors emphasize their structural, functional, predictive and prognostic features and attempt to provide the clinical context that allows improved diagnosis and therapy while building on the genetics that clarifies patterns of inheritance and predisposition to tumor development through precursor lesions. The Spectrum of Neuroendocrine Neoplasia provides a broad overview of neuroendocrine neoplasms using a practical approach to diagnosis, histological classification and therapy, and presents the most important and significant developments of the technologies used to diagnose, classify and treat them.

Do you want to be up to date on the latest concepts of diagnosis and treatment of patients suffering from disorders of the pituitary gland? Are you looking for an expert guide to the best clinical management? If so, this is the book for you, providing a full analysis of pituitary disorder management from acromegaly to Addison s Disease; from Cushing s Disease to hypopituitarism; from hormone disorders to hormone replacement Well-illustrated throughout and with contributions from leading specialists in pituitary disease, inside you ll find comprehensive and expert coverage, including: * Diagnosing pituitary disease * Management options for each disorder * Complications that can occur * Psychological and psychosocial effects of pituitary disease * What outcomes you and your patients can expect over the long term * Current research and clinical trials related to pituitary disease Pituitary Disorders: Diagnosis and Management is the perfect clinical tool for physicians and health care providers from many related disciplines, and an essential companion for the best quality management of pituitary patients.

The pituitary gland is the "master gland" that regulates many of the functions of other endocrine glands and their target tissues throughout the body. There is virtually no organ or tissue that is not affected, directly or indirectly, by the hormones that are secreted by the anterior and posterior pituitary. Pituitary dysfunction is a common clinical scenario. However the manifestations of pituitary disease vary from florid clinical features that can readily be identified and recognised as pituitary in etiology, to more subtle and non-specific problems that are often overlooked or misdiagnosed, leaving the relationship to pituitary malfunction unnoticed. The former, conditions such as florid acromegaly and Cushing's disease, are only a minority of pituitary pathologies, hence the misconception that pituitary disease is rare. The most common disorder is the pituitary adenoma, a lesion that is increasingly recognised as a highly-prevalent finding identified in up to 20% of the population. Although many of these are considered to be incidental findings, many have unrecognised impact on fertility, longevity and quality of life, and their clinical significance is increasingly gaining attention. Moreover, the management of these lesions has seen major changes with the development of new pharmacotherapeutic agents, improved minimally invasive surgical approaches and targeted radiotherapeutic techniques. There has been significant progress in understanding pituitary development, physiology and pathology, and these are all discussed in this new edition. The classification of pituitary disease is becoming easier, and as targeted therapies are being developed, the role of the pathologist in determining accurate diagnoses is increasingly important. The surgical pathologist must therefore recognise the important role of morphologic analysis in classifying sellar pathology for the diagnosis and management of the pituitary patient.